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Could a Hot Cup of Tea Preserve Your Vision?

Original post: https://www.webmd.com/eye-health/news/20171214/could-a-hot-cup-of-tea-preserve-your-vision?src=RSS_PUBLIC

The study of U.S. adults found that people who drank hot tea on a daily basis were 74 percent less likely to have glaucoma, compared to those who were not tea fans.

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Characterization of SPP inhibitors suppressing propagation of HCV and protozoa [Microbiology]

Original post: http://www.pnas.org/content/114/50/E10782.short?rss=1

Signal peptide peptidase (SPP) is an intramembrane aspartic protease involved in the maturation of the core protein of hepatitis C virus (HCV). The processing of HCV core protein by SPP has been reported to be critical for the propagation and pathogenesis of HCV. Here we examined the inhibitory activity of…

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Prenatal stress accelerates offspring growth to compensate for reduced maternal investment across mammals [Anthropology]

Original post: http://www.pnas.org/content/114/50/E10658.short?rss=1

Across mammals, prenatal maternal stress (PREMS) affects many aspects of offspring development, including offspring growth. However, how PREMS translates to offspring growth is inconsistent, even within species. To explain the full range of reported effects of prenatal adversity on offspring growth, we propose an integrative hypothesis: developmental constraints and a…

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Feeling Sexually Harassed? You're Not Alone

Original post: https://www.webmd.com/women/news/20171214/feeling-sexually-harassed-youre-not-alone?src=RSS_PUBLIC

Among women 18 to 29 years old, 60 percent said they or a female family member had been sexually harassed.

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Temporal changes in the documentation of neurological findings among patients with acute ischaemic stroke in a single centre in Japan: a retrospective cross-sectional study

Original post: http://bmjopen.bmj.com/cgi/content/short/7/12/e019480?rss=1

Objective

To evaluate temporal differences in the documentation of neurological findings by the same physicians in patients with ischaemic stroke while in hospital. We also investigated differences in the rate of documentation of neurological findings in patients with stroke between internists and neurosurgeons.

Design

A retrospective medical chart review.

Participants

Hospitalised adult patients with acute ischaemic stroke who stayed 7 or more days in our hospital. Neurosurgeons (n=8) and internists (n=19) caring for these patients (including up to 10 patients per physician).

Main outcome measures

The documentation rate of any neurological finding in the patients on each day (from day 1 to 7 and on discharge). The documentation rates of eight neurological finding components (consciousness, mental status, cranial nerves, motor function, sensory function, coordination, reflexes and gait). We included only documentation by the same physician. Fisher’s exact test was used to evaluate differences in outcomes between neurosurgeons and internists.

Results

During the study period, we identified 172 patients with stroke who were cared for by 27 phys

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Risk factors for feelings of sadness and suicide attempts among cancer survivors in South Korea: findings from nationwide cross-sectional study (KNHANES IV-VI)

Original post: http://bmjopen.bmj.com/cgi/content/short/7/12/e016130?rss=1

Introduction

As the number of cancer survivors is rapidly increasing with the increased incidence of the disease and improved survival of patients, the prevalence of, and risk factors for, mental health problems and suicidality among cancer survivors should be examined.

Methods and analysis

Using data obtained from the Korean National Health and Nutrition Examination Survey (2007–2013), we examined 1285 and 33 772 participants who had been and never been diagnosed with cancer, respectively. We investigated the risks of feelings of sadness and suicide attempts among cancer survivors and general population and examined differences in the risks of cancer survivors among subgroups according to cancer-related characteristics.

Results

The median age of survivors at the time of the survey and at diagnosis was 63 and 54 years, respectively. After adjusting for sex, level of education, household income, occupation, marital status, cancer type, current status of treatment, age at diagnosis and years since diagnosis, the risk of suicide attempts was significantly higher in participants diagnosed with cancer before 45 years of age compared with those diagnosed at 45&nd

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Informatics competencies for nurse leaders: protocol for a scoping review

Original post: http://bmjopen.bmj.com/cgi/content/short/7/12/e018855?rss=1

Introduction

Globally, health information technologies are now being used by nurses in a variety of settings. However, nurse leaders often do not have the necessary strategic and tactical informatics competencies to adequately ensure their effective adoption and use. Although informatics competencies and competency frameworks have been identified and developed, to date there has not been review or consolidation of the work completed in this area. In order to address this gap, a scoping review is being conducted. The objectives of this scoping review are to: (1) identify informatics competencies of relevance to nurse leaders, (2) identify frameworks or theories that have been used to develop informatics competencies for nurse leaders, (3) identify instruments used to assess the informatics competencies of nurse leaders and (4) examine the psychometric properties of identified instruments.

Methods

Using the Arksey and O’Malley five-step framework, a literature review will be conducted using a scoping review methodology. The search will encompass academic and grey literature and include two primary databases and five secondary databases. Identified studies and documen

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Mapping Evidence of Patients Experiences in Integrated Care Settings: A Protocol for a Scoping Review

Original post: http://bmjopen.bmj.com/cgi/content/short/7/12/e018311?rss=1

Introduction

Integrated care (IC) models have emerged to address gaps in care for individuals with complex healthcare needs. Although the clinical and cost-effectiveness of IC models are well-established, our understanding of whether IC models facilitate a patient-centred care experience from the patients’ perspective is not well understood. This scoping review aims to comprehensively map the literature to provide a broad overview of patients’ experiences in IC settings with a focus on the experiences of complex patients with comorbid mental and physical illnesses. It also aims to describe current gaps identified in the literature in our understanding of aspects of care that are often unrecognised.

Methods and analysis

Using established scoping review frameworks and guidelines, we will perform a comprehensive search in the following databases: MEDLINE, EMBASE, PsycINFO, CINAHL, AMED and the Cochrane Library to identify relevant studies on patients’ experiences in IC models. Grey literature sources and studies bibliographies will also be searched to identify relevant studies and documents. Data will be extracted and summarised using descriptive statistic

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Precision genome editing using synthesis-dependent repair of Cas9-induced DNA breaks [Genetics]

Original post: http://www.pnas.org/content/114/50/E10745.short?rss=1

The RNA-guided DNA endonuclease Cas9 has emerged as a powerful tool for genome engineering. Cas9 creates targeted double-stranded breaks (DSBs) in the genome. Knockin of specific mutations (precision genome editing) requires homology-directed repair (HDR) of the DSB by synthetic donor DNAs containing the desired edits, but HDR has been reported…

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Excess Weight May Raise Rosacea Risk

Original post: https://www.webmd.com/skin-problems-and-treatments/news/20171215/excess-weight-may-raise-rosacea-risk?src=RSS_PUBLIC

Their large new study found that the risk for rosacea increases among women as weight rises.

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